Smoking cessation in adults with diabetes: a systematic review and meta-analysis of data from randomised controlled trials.
Esiste un modo che funziona per aiutare chi ha il diabete a smettere di fumare?
Revisione sistematica e meta-analisi degli studi randomizzati sugli interventi per smettere di fumare in persone con diabete di tipo 1 o 2, con ricerca su MEDLINE, EMBASE, CINAHL e PsycINFO fino a settembre 2013, in cure primarie, secondarie e terziarie. L'esito principale era la cessazione VERIFICATA BIOCHIMICAMENTE, non quella dichiarata. Sono state esaminate 1.783 citazioni e riesaminati sette articoli che riportavano otto studi su 872 partecipanti; tutti gli studi duravano 6 mesi, e tre includevano una terapia farmacologica. Il rapporto di rischio della cessazione verificata biochimicamente per gli interventi PIU' intensivi rispetto a quelli meno intensivi era 1,32 (IC 95% da 0,23 a 7,43), con eterogeneita' significativa (I2 = 76%). Un solo studio riportava misure di controllo glicemico. Gli autori concludono che c'e' ASSENZA DI PROVE di efficacia per gli interventi piu' intensivi nelle persone con diabete, e che la ricerca futura dovrebbe usare interventi multicomponente di almeno un anno e misurare anche l'effetto sulla glicemia. Nell'introduzione gli autori richiamano che, secondo una precedente meta-analisi di studi prospettici nel diabete, il fumo aumenta il rischio di morte del 48%, di cardiopatia coronarica del 54%, di ictus del 44% e di infarto del 52%, e che il rischio di cardiopatia, ictus e proteinuria e' direttamente legato al numero di sigarette al giorno.
Due messaggi opposti, e vanno tenuti insieme. Il primo: nel diabete il fumo pesa moltissimo -- quasi il 50% di morte in piu', oltre il 50% di infarto -- e il danno cresce con le sigarette, quindi anche ridurre conta. Il secondo, scomodo: NON sappiamo quale aiuto funzioni meglio. L'intervallo di confidenza di questo risultato va da 0,23 a 7,43, cioe' e' compatibile sia con un intervento che dimezza le probabilita' sia con uno che le moltiplica per sette: non e' un risultato debole, e' un non-risultato, su 872 persone e sei mesi. Come si traduce: chi vuole smettere non deve aspettare il programma perfetto perche' non e' stato individuato, e non deve leggere un tentativo fallito come una propria colpa -- gli studi dicono che nemmeno i programmi strutturati mostrano un vantaggio chiaro. La strada resta chiedere aiuto al medico o a un centro antifumo, dove ci sono i farmaci e il supporto, e riprovare. Nota importante: la ricerca si ferma al 2013 e gli studi durano sei mesi; gli stessi autori dicono che servirebbero interventi di almeno un anno. L'assenza di prove non e' prova che non serva a niente.
Abstract (in lingua originale)
Testo integrale (Open Access, in lingua originale)
Introduction
For adults with diabetes, as in the wider population, smoking is associated with an increased risk of cardiovascular events and death. A recent systematic review and meta-analysis of prospective studies on diabetes reported that smoking increased the risk of death by 48%, coronary heart disease by 54%, stroke by 44% and myocardial infarction by 52%.1 The risk for coronary heart disease, stroke and proteinuria is directly related to the number of cigarettes smoked per day.2 3 Patients with diabetes who smoke have higher glycated haemoglobin (HbA1c) levels4 and are more likely to experience severe hypoglycaemia.5
People with diabetes who stop smoking are likely to have a lower risk of death and cardiovascular events compared with those who continue to smoke.1 Smoking cessation is also associated with a reduction in levels of albuminuria, improvement of glycaemic control and lipid profile.6 Smoking cessation has been recommended as a routine component of the treatment of diabetes by the American Diabetes Association,7 although evidence to guide best practice is limited.8
People with diabetes are faced with the challenge of extensive changes in their lifestyle, a burden that may be increased by attempts to stop smoking.9 10 Tailoring smoking cessation programmes to the needs of people with diabetes may lead to improved outcomes compared with usual care, but may also further increase the burden of self-management. Concerns have also been expressed regarding weight gain associated with smoking cessation.11
We, therefore, carried out a systematic review of randomised controlled trials reporting the effects of smoking cessation interventions in diabetes to inform clinical practice and identify potential for further research to improve patient outcomes.
Methods
We carried out this systematic review in accordance with the study protocol (see online supplementary appendix 1).12 Peer-reviewed journal articles and conference abstracts that reported the results of a randomised controlled trial and met the following eligibility criteria were eligible for inclusion: trials recruiting non-pregnant adults with type 1 or type 2 diabetes who smoked at baseline, evaluating pharmacological or non-pharmacological interventions intended to support smoking cessation (more intensive interventions) compared to usual care, counselling or optional medication (less intensive interventions). We included trials reporting at least one of the following outcomes: (1) smoking cessation, (2) glycaemic control, (3) weight. There were no restrictions on length of follow-up or language of publication. We included trials that did not report biochemically verified smoking cessation to fully capture the available evidence, characterise smoking status as reported in these trials and to add to the available data from which we could analyse effects of interventions on glycaemic control and weight where such additional data were available.
We based our search strategy on that used by the Cochrane Tobacco Addiction Group13 for identifying randomised controlled trials of smoking cessation together with the Cochrane Metabolic and Endocrine Disorders Group14 search strategy for interventions in type 1 or type 2 diabetes using the high sensitivity options (see online supplementary appendix 2).
We searched the following online databases: Cochrane Central Register of Controlled Trials [The Cochrane Library, Wiley] (Issue 9, 2013), MEDLINE [OvidSP] (1946—present), EMBASE [OvidSP] (1974—present), CINAHL [EbscoHOST] (1980—present), PsycINFO [OvidSP] (1967—present) and Science Citation Index, Social Sciences Citation Index, Conference Proceedings Citation Index- Science & Conference Proceedings Citation Index—Social Science & Humanities [Web of Knowledge] (1945—present). The most recent search date was 3 September 2013. We also searched clinicaltrials.gov, isrctn.org, anzctr.org.au and International Clinical Trials Registry Platform for ongoing trials. References from bibliographies of included trial reports and results of a search on Web of Science Citation Index for those reports were also reviewed. We contacted authors of potentially eligible conference abstracts.
Two reviewers (AN and RB) independently screened the titles and abstracts of identified citations to select those requiring full-text assessment. Where there was disagreement, a third reviewer (AF) assessed the records to reach a consensus. Full-text articles were further assessed and data were entered into a prespecified table including 12 entry fields (see online supplementary appendix 3). The data extraction table included information on: (1) trial methodology, setting and duration of follow-up; (2) population characteristics; (3) type of intervention and (4) analyses and outcomes.
Data reported for intention-to-treat analyses were selected at the longest follow-up point. We assumed a diagnosis of type 1 diabetes in insulin-treated participants if the type of diabetes was not otherwise specified.
We used the Cochrane Collaboration’s tool to assess risk of bias at the outcome level.15 Bias was assessed in duplicate with disagreements resolved by a third reviewer. The assessed domains were random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment and completeness of outcome data. Trials deemed to have a high risk of detection bias due to assessing only self-reported smoking cessation were not included in the primary analysis of objectively measured cessation data.
The risk ratio (RR) for biochemically verified smoking cessation with 95% CI was the primary outcome measure in this analysis. We made an a priori decision to use the random effect model to take into account the variability of studied populations and intervention types. The meta-analysis was carried out in Review Manager V.5.2.3 (The Nordic Cochrane Centre, Copenhagen, Denmark) using Mantel-Haenszel method, Cochran's χ2 test and the I2 statistic to assess heterogeneity. The main meta-analysis included all measures of biochemically verified smoking cessation outcomes. We also pooled data on self-reported smoking cessation: (1) in all eligible trials and (2) in trials with biochemically verified smoking cessation. We calculated pooled means and SDs and obtained SDs from SEs of the mean using formulas recommended by the Cochrane Collaboration.16
Results
A total of 2914 citations were identified (figure 1) from electronic searches. A further 15 relevant publications were identified as citing or cited by included trial reports. After removing duplicates we screened 1783 citations. Based on the title and abstract, 1669 were assessed as ineligible. The full text of the remaining 114 articles was assessed for eligibility. Most were excluded as not reporting a randomised controlled trial (n=43), or included patients who did not have diabetes (n=29) or did not smoke (n=26). One potentially eligible conference abstract could not be retrieved. We contacted the first author, but received no reply. We selected seven articles reporting eight trials for inclusion.
Flow diagram of literature search, screening and selection for analysis.
All eight trials were reported in English and had a 6-month maximum duration of follow-up. Two were reported in a single article.17 Three trials were carried out in Europe,18–20 two in Asia,21 22 two in Australia17 and one in North America.23
In total, 872 smokers with type 1 or type 2 diabetes participated in the reviewed trials (table 1). Three trials reported in two publications17 21 did not include information on the type of diabetes. Two trials21 22 included only men.
Characteristics of trials included in the analysis
* Primary outcome unless it was not specified in the article.
† Assumption on the type of diabetes was made on the basis of reported treatment with insulin.
CO, carbon monoxide; NRT, nicotine replacement therapy; T1D, type 1 diabetes; T2D, type 2 diabetes.
Five trials assessed either non-pharmacological interventions to support smoking cessation17 19 21 or referral to a smoking cessation clinic.22 Interventions reported in three other trials included optional nicotine replacement therapy (NRT) without bupropion18 20 or with bupropion.23
The intervention was delivered by nursing staff or allied health professionals in three trials18 20 23 and by both doctors and nursing staff or allied health professionals in two trials.19 21 In one trial, the intervention included advice from a doctor and referral to cessation clinic.22 In two other trials, intervention delivery was not specified.17 The interventions were not specifically tailored for people with diabetes apart from the inclusion of educational components focusing on the effects of smoking on the complications of diabetes and glycaemic control.
We did not identify any trials that specifically assessed pharmacological interventions, although among the three identified ongoing trials not included in this review, one European trial assesses the efficacy and safety of smoking cessation with varenicline tartrate in patients with diabetes.24 The two other ongoing trials carried out in North America25 and Asia26 assess the effectiveness of behavioural interventions.
The less intensive intervention comparator groups received usual care, involving advice to stop smoking in three trials,20 22 23 counselling about general health risks of smoking in another three trials17 21 22 and diabetes-specific counselling in one trial.17 In one trial, optional NRT was reported as used in addition to counselling in the comparator group.18
Four of eight trials included a definition of the primary outcome (table 2). In four trials, smoking cessation was biochemically verified using concentration of breath carbon monoxide (CO),19 urinary cotinine19 20 or salivary cotinine.23 Two trials assessed only self-reported cessation,21 22 and two trials reported only a total number of people with biochemically verified cessation in the study population.17 All trials measured smoking cessation as point prevalence abstinence.
Outcomes and effect sizes of interventions to support smoking cessation
Data presented as number of events (%) or mean (SD).
CO, carbon monoxide; HbA1c, glycated haemoglobin.
All trials were deemed to have low risk of attrition bias and most trials were assessed as having low risk of detection bias (figure 2, see online supplementary appendix 4). Most trials provided incomplete information on random sequence generation, allocation concealment and blinding of participants and personnel.
Summary of authors’ judgements on the risk of bias in reviewed trials.
Trial findings are summarised in table 2. One article reporting two trials included only the overall number of patients who stopped smoking in both trials.17 Two trials21 22 were excluded from pooled analysis due to high risk of detection bias as a consequence of self-reported cessation outcomes.
Pooled data from the four trials18–20 23 that reported point prevalence of biochemically verified smoking cessation in both trial arms are summarised in figure 3. For 543 participants, 44 smoking cessation events are reported. The likelihood of biochemically verified smoking cessation was 32% higher in patients who received more intensive intervention compared with less intensive intervention, although this effect was not significant (RR 1.32, 95% CI 0.23 to 7.43).
Forest plot showing pooled analysis of trials reporting biochemically verified point prevalence of smoking cessation.
There was substantial heterogeneity between the results of trials included in the pooled analysis of the primary outcome (χ2 test for heterogeneity, p=0.006; I2=76%). Two trials,18 19 jointly accounting for 44% of the weight of these results, reported point estimates of effects that suggested a greater likelihood of smoking cessation in the less intensive intervention group compared with the more intensive intervention group. In one trial,19 the only biochemically verified incident of smoking cessation was recorded in a less intensive intervention group patient who stopped smoking after sustaining a myocardial infarction.
In the pooled analyses of self-reported smoking cessation outcomes in (1) all eligible trials and (2) in trials also reporting biochemically verified smoking cessation, participants allocated to more intensive intervention had, respectively, 1.85 times (RR 1.85, 95% CI 0.81 to 4.22) or 1.39 times (RR 1.39, 95% CI 0.28 to 6.92) greater likelihood of cessation compared with patients allocated to the less intensive intervention.
Other outcomes reported related to smoking outcomes and metabolic outcomes (table 2). Continuous measures of urinary cotinine–creatinine ratio and breath CO were reported for one trial,19 but the results were not compared between allocated trial groups. In one trial,23 proportions of patients with HbA1c <7% (53 mmol/mol) in more intensive and less intensive intervention groups were reported at 6 months (61% vs 75%), but were not significantly different (p=0.16). No trials reported other objectively measured short-term or long-term cardiovascular risk or safety data.
Discussion
Despite an excess cardiovascular risk in people with diabetes, we have identified only a small number of trials evaluating the effect of smoking cessation interventions in this group. Interventions tested in the trials were similar to those used in the general population and included counselling, referral and advice, with, for some, the addition of diabetes-specific education. Interventions and comparator groups were heterogeneous and the pooled results did not provide evidence of efficacy for smoking cessation interventions in people with diabetes. Only one trial reported data on glycaemic outcomes, which were not significantly different between intervention groups.
This is, to our knowledge, the first systematic review of randomised trials of smoking cessation interventions in diabetes. Our analysis includes equal numbers of studies reporting positive and negative effect estimates, which reduces the likelihood of publication bias. The statistical power of the meta-analysis is limited by the small number of trials published to date and a relatively small number of participants in the published trials. Limited statistical power may partially explain the lack of significant findings in the pooled analysis. There are too few trials to draw conclusions about the types of intervention, and differences between type 1 and type 2 diabetes. The extent of heterogeneity in interventions, and intervention and comparator groups, also limited our ability to draw conclusions based on our findings. Most of the included trials provided incomplete information on randomisation, allocation concealment and blinding of participants and personnel which may potentially introduce bias at the level of individual trials.
This review does not include trials in which smoking cessation was a part of a more extensive complex intervention and in which only a proportion of patients had diabetes and smoked at baseline. This limited the number of trials to be reviewed and the size of reviewed population, but allowed us to measure specifically the effect of smoking cessation by reducing the extent of performance bias and detection bias arising from multiple interventions and multiple measurements.
Some studies suggest that smokers with diabetes may be more motivated to stop smoking, than the general smoker population27 and more likely to stop smoking after hospitalisation compared with patients without diabetes.28 There is no evidence from our review that, if such motivation is present, it translates into improved outcomes. In other high-risk patient groups, for example, chronic obstructive pulmonary disease29 and cardiovascular disease,30 higher point estimates of the effect of intervention on smoking cessation are reported with most trials extending to 12-month follow-up.
An earlier, narrative review has examined the issues associated with smoking cessation in diabetes and identified some of the reasons why evaluation of smoking cessation interventions in this group may have been dealt with cautiously.8 The datasheets for most recommended first-line smoking cessation medications31 caution against their use in diabetes.8 32 Moreover, studies report that smoking cessation may worsen metabolic profile and glycaemic control33 34 and lead to weight gain.35 We have identified four trials not included in the narrative review, two predating the narrative review.17 19
Further data from randomised trials of interventions evaluating smoking outcomes, weight change and glycaemic control would inform treatment strategies in a population in which smoking cessation is likely to have high absolute benefits.1 The issue of safety of such treatments is partly addressed in an ongoing trial of varenicline for smoking cessation in diabetes,24 but the follow-up period of 6 months is likely to be too short to identify sustained effects. Trials assessing combinations of NRT with varenicline or bupropion in addition to non-pharmacological interventions may, in any case, better reflect clinical practice.31
Despite the potential health benefits of smoking cessation in diabetes, there has been limited work on developing and evaluating tailored interventions to support smoking cessation in these patients. From a health services perspective, it would be important to know whether a tailored intervention is more effective in this patient group than providing the same management as for the general population. Given the high burden of self-management required of people with diabetes, it is possible that integrating an intervention with routine care may be more effective than managing the problem separately. Further work is needed to explore the role of this approach in clinical care using trial designs with follow-up extending to at least 1 year.